Deep Learning-Based Design of Cell-Targeting Ligands Enables Functional siRNA Delivery in Multiple Extrahepatic Tissues
Time: 12:00 pm
day: Conference Day Two
Details:
- Unconjugated oligotherapeutics (e.g. siRNAs) have major limitations in targeted delivery
- De novo protein-based ligands that selectively bind receptors of interest are rapidly designed via deep learning and screened in vitro
- Conjugating cell-targeting ligands to gene-targeting siRNAs leads to robust and selective in vivo knockdown in multiple target tissues
